Clinical Guidelines

Clinical Guidelines

Evidence-based clinical guidance for the diagnosis and management of myelodysplastic syndromes, supporting healthcare professionals worldwide in delivering optimal patient care.

International Guidelines

Diagnosis & Classification

  • WHO Classification 2022
    Latest diagnostic criteria and classification system
  • ICC Classification
    International Consensus Classification guidelines
  • Molecular Diagnostics
    NGS testing and mutation analysis protocols
  • Cytogenetic Analysis
    Karyotyping and FISH testing standards

Risk Stratification

  • IPSS-R Scoring
    Revised International Prognostic Scoring System
  • IPSS-M Molecular
    Molecular-based prognostic scoring
  • WPSS System
    WHO-based Prognostic Scoring System
  • Risk Assessment Tools
    Clinical calculators and decision support

Treatment Guidelines

Lower-Risk MDS

  • Anemia Management
    ESA therapy and transfusion support
  • Luspatercept
    First-in-class erythroid maturation agent
  • Lenalidomide
    Treatment for del(5q) MDS
  • Iron Chelation
    Managing transfusional iron overload

Higher-Risk MDS

  • Hypomethylating Agents
    Azacitidine and decitabine protocols
  • Stem Cell Transplant
    Allogeneic HSCT guidelines and timing
  • Clinical Trials
    Novel therapies and combination approaches
  • Supportive Care
    Comprehensive management strategies

Regional Guidelines

Europe

  • EHA Clinical Practice Guidelines
  • ESMO Management Recommendations
  • National Society Guidelines (UK, France, Germany)
  • EMA Regulatory Guidance

North America

  • NCCN Clinical Practice Guidelines
  • ASH Evidence-Based Reviews
  • CAP Laboratory Standards
  • FDA Regulatory Framework

Asia-Pacific

  • JSMO Japanese Guidelines
  • CSCO Chinese Consensus
  • Regional Expert Recommendations
  • Access and Reimbursement Guidance

Guideline Resources

ResourceOrganizationLast Updated
MDS Diagnosis & TreatmentNCCN2024
MDS Management GuidelinesEHA2023
Laboratory Testing StandardsCAP2023
Supportive Care GuidelinesMASCC2023

For Healthcare Professionals

MDSA works closely with international guideline development organizations to ensure clinical practice guidelines:

  • Incorporate latest research evidence
  • Reflect real-world clinical practice
  • Include patient perspectives and priorities
  • Address global treatment access challenges
  • Provide practical implementation guidance
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